2026

 

Fang, W., Cheng, B., Pastor, S., Zobel, M.J., Porras, T., Wu, H-W., Kondapally, T., Roberts, S.S., Parekh, C., Tsai, J.W., Tsakiridis, A., Barbaric, I., Asgharzadeh, S., Maris, J.M., Huang, M. (2026). A Human Stem Cell Model of Neuroblastoma Identifies Four Chromosome 17q Genes that Drive Tumor Initiation and Progression. Cancer Lett.
DOI: 10.1016/j.canlet.2026.218781

 

Jestice, L.H., Butler, L., Lea, R. A.,  Adamson, K.I., Van Lent, J., Johnson, S.L., Weedon, H., D'Silva, E., Gelezauskaite, G., Asselbergh, B., Brown, E., Laing, O., C, Price, C.J., Stavish, D., Tsakiridis, A., Collins, M.O., Timmerman, V., De Vos, K.J., Twelvetrees, A.E, Grierson, A.J., Barbaric, I. (2026). HDAC6 inhibition alleviates mitochondrial trafficking in novel models of Charcot-Marie-Tooth Disease Type 2A. JCI Insight. DOI: 10.1172/jci.insight.200106

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Moreno-Gonzalez,  C., Cameron, D.,  Marques Moreno,  M, Desjardins, J.,  Minckley,  T.,  Bailey,  M., Hagemann, C.,  Bhatt,  S., Tsakiridis, A., Serio, A., Liu, K.J. (2026). Dynamic modelling of human neural crest development using a bioengineered stem cell organoid system. bioRxiv. DOI:  https://doi.org/10.64898/2026.05.04.721958

 

Gogolou, A.,  Stefanidis, N.,   Blin, G.,  Strawbridge, S.S.,  Fletcher, A.G., Tsakiridis, A. (2026) Notch signalling governs human enteric nervous system progenitor dynamics. bioRxiv. DOI: https://doi.org/10.64898/2026.05.01.722150

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Uyulgan, S., Sedas Perez, S., Towers, M*, Tsakiridis, A*. (2026) Generation of human hindlimb/genital tubercle progenitors from pluripotent stem cells. bioRxiv. DOI: https://doi.org/10.64898/2026.04.14.718471

*joint corresponding authors

 

Sabahi-Kaviani, R., Gogolou, A., Souilhol, C., van der Kroeg, M., Kushner, S.A.,  de Vrij, F.M.S., Tsakiridis, A., Luttge, R. (2026). Nervous System-on-Chip: Innovative Microfluidic Platform to Compartmentalize hiPSC-Derived Neural Networks. Micromachines. DOI: 10.3390/mi17020199

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​Harron, K.L., Jevans, B., Allin, B.S.R., Davidson, J.R., Tsakiridis, A., Andrews, P.W.A., De Coppi, P., McCann, C.J. (2026) Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England. Frontline Gastroenterol. DOI: https://doi.org/10.1136/flgastro-2025-103478

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2025

 

Wong, F.C.K, Zhang, M., Thomson, E., Schumacher, L.J., Tsakiridis, A., Ashmore, J., Tong, L., Blin, G., Karagianni, E., Mullin, N.P., Chambers, I. Wilson, V. (2025). NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction. EMBO J. DOI:10.1038/s44318-025-00527-9

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Jevans, B., Cooper, C., Peruzza, L., Perin, S., Li, S., McAteer, T., De Coppi, P., Andrews, P.W., Tsakiridis, A., McCann , C.J. (2025) Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease. bioRxiv. DOI: https://doi.org/10.1101/2025.10.16.679985
 

2024

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Jevans, B., Cooper, F., Fatieieva, Y., Gogolou, A., Kang Y-N., Restuadi, R., Vanden Bergh, P., Adameyko, I., Thapar, N., Andrews, P.,  De Coppi, P., Tsakiridis, A.*, McCann*, C. (2024) Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue. Gut. DOI: 0.1136/gutjnl-2023-331532​

*joint corresponding authors​

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Saldana-Guerrero, I.M., Montano-Gutierrez, L., Boswell, K., Hafemeister, C., Pool, E., Shaw, L.E., Stavish, D., Lea, R.A., Wernig-Zorc, S., Bozsaky, E., Fetahu, I.S., Zoescher, P.,  Pötschger, U., Bernkopf, M.,Wenninger-Weinzierl, A., Sturtzel, C., Souilhol, C., Tarelli, S., Shoeb, M.R.,  Bozatzi, P., Rados, M., Guarini, M., Buri, M.C., Weninger, W., Putz, E.M., Huang, M., Ladenstein, R., Andrews, P.W., Barbaric, I., Cresswell, G.D., Bryant, H.E., Distel, M., Chesler, L., Taschner-Mandl, S., Farlik, M., Tsakiridis, A*., Halbritter, F*. (2024)  A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations. Nat Commun. DOI: 10.1038/s41467-024-47945-7.

*joint corresponding authors

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Cooper, F*.,  Souilhol, C., Haston, C. Gray, S., Boswell, K.,  Gogolou, A., Frith, T.,  Stavish, D., James, B.M.,  Bose, D.A.,  Dale, J.K., Tsakiridis, A*. (2024) Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors. Development. DOI: 10.1242/dev.202098. 

*joint corresponding authors

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2022

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Gogolou, A., Souilhol, C., Granata, I., Wymeersch, F.J., Manipur, I., Wind, M., Frith, T. J. R., Guarini, M., Bertero, A., Bock, C., Halbritter, F., Takasato, M., Guarracino, M. R.,Tsakiridis, A. (2022). Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. eLife. DOI: 10.7554/eLife.74263. 

 

Cooper, F. & Tsakiridis, A. (2022). Towards clinical applications of in vitro-derived axial progenitors. Dev Biol. DOI: 10.1016/j.ydbio.2022.06.006. 

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Cooper, F. & Tsakiridis, A. (2022). Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells. Biochem Soc Trans. DOI: 10.1042/BST20211152

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2021​

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Wind, M. & Tsakiridis A. (2021).  In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells. Curr Protoc. DOI: 10.1002/cpz1.244.

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Gogolou, A., Frith, T.J.R, Tsakiridis A. (2021). Generating Enteric Nervous System Progenitors from Human Pluripotent Stem Cells. Curr Protoc. DOI: 10.1002/cpz1.137.

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Wind, M., Gogolou, A., Manipur, I., Granata, I., Butler, L., Andrews, P. W., Barbaric, I., Ke, N., Guarracino, M. R., Placzek, M., Tsakiridis, A. (2021). Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives. Development. DOI: 10.1242/dev.194415.

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Wymeersch, F.J., Wilson, V., Tsakiridis, A. (2021). Understanding axial progenitor biology in vivo and in vitro. Development. DOI: 10.1242/dev.180612.

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2020

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Frith, T.J.R*, Gogolou, A., Hackland, J.O.S., Hewitt, Z.A, Moore, H.D., Barbaric, I., Thapar, N., Burns, A., Andrews, P.W.A., Tsakiridis, A*., McCann, C*. (2020) Retinoic acid accelerates the specification of enteric neural progenitors from in vitro-derived neural crest. Stem Cell Reports. DOI: https://doi.org/10.1016/j.stemcr.2020.07.024

*joint corresponding authors

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Ruske, L.J., Kursawe, J., Tsakiridis, A., Wilson, V., Fletcher, A.G., Blythe, R.A., Schumacher, L.J. (2020) Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots. Phys. Biol.  DOI: https://doi.org/10.1088/1478-3975/aba041

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2019

Frith, T.J.R. & Tsakiridis, A. (2019) Efficient generation of trunk neural crest and sympathetic neurons from human pluripotent stem cells via a neuromesodermal axial progenitor intermediate. Curr Protoc Stem Cell Biol. DOI: 10.1002/cpsc.81. 

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2018

Sutherland, l., Ruhe, M., Gattegno, D., Mann, K., Greaves, J., Koscielniak, M., Meek, S., Lu, Z., Waterfall, M., Taylor, R., Tsakiridis, A., Brown, H., Maciver, S., Joshi, A., Clinton, M., Chamberlain, L., Smith, A., Burdon, T. (2018). LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein. J Cell Sci.  DOI: 10.1242/jcs.222257.

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Frith, T.J.R., Granata, I., Wind, M., Stout, E., Thompson, O., Neumman, K., Stavish, D., Heath, P.R., Hackland, J.O.S., Ortmann, D., Anastassiadis, K., Gouti, M., Briscoe, J., Wilson, V., Johnson, SL., Placzek, M., Guarracino, M.R., Andrews, P.W.A., Tsakiridis, A. (2018). Human axial progenitors generate trunk neural crest cells in vitro. eLife. DOI: 10.7554/eLife.35786. 

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Lopez-Yrigoyen, M., Fizanza, A., Cassetta, L., Axton, R.A., Taylor, H., Meseguer-Rippolles, J., Tsakiridis, A., Wilson, V., Hay, D., Pollard, J.W. & Forrester, L.M. (2018). A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells. Philos Trans R Soc Lond B Biol Sci. DOI: 10.1098/rstb.2017.0219.

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2007-2016

Economou, C*., Tsakiridis, A*, Wymeersch, F., Gordon-Keylock, S., Dewhurst, R. E., Medvinsky, A., Smith, A. J. H. & Wilson, V. (2015). Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. BMC Dev Biol. DOI:10.1186/s12861-015-0084-7

*joint first authors

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Tsakiridis, A* & Wilson, V*. (2015). Assessing the bipotency of in vitro-derived neuromesodermal progenitors. F1000Res. DOI: 10.12688/f1000research.6345.2

*joint corresponding authors

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Gouti, M*., Tsakiridis, A*., Wymeersch, F., Huang, Y., Kleinjung, J., Wilson, V. & Briscoe, J. (2014). In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PloS Biol. DOI: 10.1371/journal.pbio.1001937

*joint first authors

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Tsakiridis, A*., Huang, Y., Blin, G., Skylaki, S., Wymeersch, F., Osorno, R., Economou, C., Karagianni, E., Zhao, S., Lowell, S. & Wilson, V*. (2014). Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development. DOI: 10.1242/dev.101014

*joint corresponding authors

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Huang, Y., Osorno, R., Tsakiridis, A. & Wilson, V. (2012). The in vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Cell Reports. DOI: 10.1016/j.celrep.2012.10.022

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Osorno, R*., Tsakiridis, A*., Wong, F., Cambray, N., Economou, C., Wilkie, R., Blin, G., Scotting, P. J., Chambers, I. & Wilson, V. (2012). The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development. DOI:10.1242/dev.078071

*joint first authors

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Brickman, J.M., Tsakiridis, A., To, C. & Stanford, W.L. (2010). A wider context for gene trap mutagenesis. Methods Enzymol. DOI: 10.1016/S0076-6879(10)77014-2

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Tsakiridis, A., Tzouanakou, E., Rahman, A., Colby, D., Axton, R., Chambers, I., Wilson, V., Forrester, L. & Brickman, J.M. (2009). Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res. DOI: 10.1093/nar/gkp640

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Tsakiridis, A., Alexander, L.M., Gennet, N., Livigni, A., Sanchez-Martin, R.M., Li, M., Bradley, M. & Brickman, J.M. (2009). Microsphere-based tracing and molecular delivery in embryonic stem cells. Biomaterials. DOI: 10.1016/j.biomaterials.2009.06.024

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Sanchez-Martin, R.M., Alexander, L.M., Muzerelle, M., Cardenas-Maestre, J.M., Tsakiridis, A., Brickman J.M. & Bradley, M. (2009). Microsphere-mediated protein delivery into cells. Chembiochem.  DOI: 10.1002/cbic.200900136

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Tsakiridis, A., Tzouanacou, E., Larralde, O., Watts, T.M., Wilson, V., Forrester, L. & Brickman, J.M. (2007). A novel triple fusion reporter system for use in gene trap mutagenesis. Genesis.  DOI: 10.1002/dvg.20301

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Lab in the News​

 

•  Thanks for supporting a decade of research funding (1/10/2026). 

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• UK University collaboration to cure childhood gut disease with stem cell therapy (30/3/2026).

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• Understanding the genetic roots of aggressive childhood cancer: Research aims to improve Neuroblastoma treatment (6/3/2025).​

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• Exploring stem cell therapy for Hirschsprung disease (Gut journal podcast) (2/9/2024).

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• ​Important step forward in stem cell therapy for rare bowel disease (1/7/2024).

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• Stem cells provide new insight into genetic pathway of childhood cancer (13/5/2024).​

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• Lab Meeting with the Tsakiridis Lab. The Node (4/4/2024).

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• The people behind the papers – Fay Cooper and Anestis Tsakiridis (2024) Development (2024) 151 (3): dev202709. 

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• "Three cutting-edge projects funded into childhood neuroblastoma". Little Princess Trust (24/1/2024).

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• What are the six main types of childhood cancer research? CCLG (27/2/2023). 

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• "Research Focus – An interview with Dr Anestis Tsakiridis". CCLG (27/8/2020).